Research advances of non-coding RNA in cholangiocarcinoma

Huang Ziyue, Chen Wangming, Kang Pengcheng, Cui Yunfu, Xu Yi

Journal of Abdominal Surgery ›› 2021, Vol. 34 ›› Issue (6) : 474-478,487.

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Journal of Abdominal Surgery ›› 2021, Vol. 34 ›› Issue (6) : 474-478,487. DOI: 10.3969/j.issn.1003-5591.2021.06.012

Research advances of non-coding RNA in cholangiocarcinoma

  • Huang Ziyue, Chen Wangming, Kang Pengcheng, Cui Yunfu, Xu Yi
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Abstract

Cholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelial cells and liver cells. The onset of the disease is insidious and its etiology and mechanism have remained unknown. Thus its early diagnosis is rather difficult. And the incidence and mortality of the disease are rising year by year. With a rapid development of bioinformatics, it has been found that there is a close relationship between uncontrolled expression of non-coding RNA (ncRNA) and the pathogenesis of CCA. The study of ncRNA provides a new scheme for the diagnosis and treatment of CCA. Here research advances of microRNA, lncRNAs, circRNAs, piRNAs in cholangiocarcinoma were reviewed.

Key words

Cholangiocarcinoma / Non-coding RNA / MicroRNA / Long-chain non-coding RNA / CircRNA / Piwi interacting RNA

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Huang Ziyue, Chen Wangming, Kang Pengcheng, Cui Yunfu, Xu Yi. Research advances of non-coding RNA in cholangiocarcinoma[J]. Journal of Abdominal Surgery, 2021, 34(6): 474-478,487 https://doi.org/10.3969/j.issn.1003-5591.2021.06.012

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