Lin Xiangjie, Huang Wei, Yang Xuefei
Objective To compare the efficacy and safety of delayed coloanal anastomosis (DCA) versus immediate coloanal anastomosis (ICA) with temporary ostomy following surgery for low rectal cancer (LRC), thus providing valuable references for clinical surgical decision-making. Methods Articles reporting LRC surgery by DCA and ICA in English and Chinese language published from October 2013 to October 2023 were searched in the databases such as PubMed, Elsevier, Cochrane Library, CNKI, and Wanfang.The Revman 5.4 software was used to assess the quality of included literatures, and forest plots were created for meta-analysis of the corresponding observed indicators. Funnel plots were used to assess publication bias. Results A total of 15 studies(n=1 503) were included, with 937 cases in the ICA group and 566 cases in the DCA group. Compared to ICA with temporary prophylactic ostomy, patients undergoing DCA had a significantly lower incidence of overall postoperative complications(OR=0.63, 95%CI:0.41-0.96, P=0.03) and anastomotic leaks(OR=0.37, 95% CI:0.23-0.58, P<; 0.001).No significant differences were found between DCA and ICA in terms of local tumor recurrence(OR=0.94, 95%CI:0.41-2.16, P=0.89), distant tumor metastasis(OR=0.86, 95%CI:0.38-1.94, P=0.72), postoperative anastomotic stenosis(OR=0.74, 95%CI: 0.19-2.80, P=0.65), postoperative anastomotic bleeding(OR=0.35, 95% CI:0.07-1.70, P=0.19), postoperative pelvic infection(OR=0.64, 95%CI:0.35-1.18, P=0.15), postoperative sepsis(OR=1.30, 95%CI:0.36-4.72, P=0.69), postoperative intestinal obstruction (OR=0.72, 95%CI:0.15-3.35, P=0.67), postoperative dysuria (OR=0.63, 95%CI:0.25-1.56, P=0.32), and postoperative pulmonary infection (OR=1.46, 95%CI: 0.33-6.56, P=0.62). Conclusion DCA is associated with a lower incidence of overall complications and anastomotic leaks, but the rates of local tumor recurrence, distant tumor metastasis, and postoperative anastomotic stenosis, anastomotic bleeding, pelvic infection, sepsis, intestinal obstruction, dysuria, and pulmonary infection are similar to those of ICA.Therefore, DCA appears to be safe and feasible, and may serve as a safe alternative to ICA.However, further validation is required through more high-quality randomized controlled trials.